Introduction: combat damage-control resuscitation/surgery and beyond

Introduction: Beyond Illustrations.

Going beyond the Control of Quorum-Sensing to Combat Biofilm Infections.

Most bacteria attach to surfaces where they form a biofilm, cells embedded in a complex matrix of polymers. Cells in biofilms are much better protected against noxious agents than free-living cells. As a consequence it is very difficult to control pathogens with antibiotics in biofilm infections and novel targets are urgently needed. One approach aims at the communication between cells to form ...

New insights and tools to combat leprosy nerve damage.

Nerve damage no doubt is the most feared complication in leprosy since it causes most of leprosy’s characteristic and stigmatizing disabilities. Paradoxically and sadly, however, its etiology and pathogenesis remain poorly understood, its clinical management difficult and its prevention far out of sight. Leprosy nerve damage particularly occurs during leprosy reversal reactions, which represent...

Fracture mode control: a bio-inspired strategy to combat catastrophic damage

The excellent mechanical properties of natural biomaterials have attracted intense attention from researchers with focus on the strengthening and toughening mechanisms. Nevertheless, no material is unconquerable under sufficiently high load. If fracture is unavoidable, constraining the damage scope turns to be a practical way to preserve the integrity of the whole structure. Recent studies on b...

Feasibility of damage control surgery in the management of military combat casualties.

Unique and expanded applications of staged operative management are undergoing careful evaluation in many civilian level I trauma centers under the rubric of damage control surgery. Recently there have been advocates for its broad application to the early management of critically injured combat casualties. However, the enormous logistic requirements for such strategies are contrary to the deman...